San Diego · FDA-Regulated Trials

Advancing medicine,
one patient at a time.

Horizon Clinical Research connects San Diego patients with rigorously conducted, FDA-regulated clinical trials — providing access to emerging treatments, at no cost to you or your insurance.

20+
Years of Research
50+
Clinical Trials
FDA
Regulated & IRB-Monitored
#1
Enrollment Record
Our Mission

Every breakthrough starts with a patient willing to try something new.

At Horizon Clinical Research, we make that step safe, transparent, and respectful of your time. Our physician investigators bring surgical and medical expertise that is rare in the clinical trial world — and our patients feel the difference.

Research Focus

Specialized in orthopedic innovation

We focus on conditions where patients often feel they've run out of options. Our studies offer alternatives — and sometimes, the first access to treatments not yet available anywhere else.

Knee Pain

Studies exploring new approaches to knee pain, cartilage damage, and osteoarthritis — including options well beyond standard injections and joint replacement.

View Studies →

Shoulder Pain

Research into treatments for shoulder pain, rotator cuff deterioration, and joint damage — for patients seeking alternatives to surgery.

View Studies →

Cartilage Repair

Cutting-edge studies in cartilage repair, stem cell therapies, and joint preservation — the science that may shape the next generation of care.

View Studies →
Our Network

A growing San Diego research network.

Horizon is expanding from its flagship La Mesa site into a network of physician-led research sites across San Diego — bringing trials closer to more patients, and more enrollment capacity to the sponsors we partner with.

Flagship Location

La Mesa

5565 Grossmont Center Dr., Building 3, Suite 259
La Mesa, CA 91942

Now Open

La Jolla

La Jolla, CA
San Diego County

More physician-led sites are coming online across the region. Interested in partnering? →

Why Participate

Participating in research is a meaningful decision. Here's what it looks like at Horizon.

1

Study-Related Care at No Cost

All medical care tied to the study — visits, imaging, treatments — is provided at no charge to you or your insurance carrier.

2

Compensation for Your Time

Most studies offer compensation to help cover your time, travel, and effort throughout the duration of the study.

3

FDA Oversight at Every Step

Every study follows FDA guidelines and is independently monitored by an Institutional Review Board (IRB) to protect your safety.

4

Access to Emerging Treatments

Participants may gain access to therapies still in development — options that wouldn't otherwise be available outside of a research setting.

5

Your Choice, Always

You can ask questions, take time to decide, and withdraw from a study at any point — for any reason, with no obligation whatsoever.

6

Physician-Led, Patient-Centered

Our principal investigators are board-certified physicians who practice what they study — bringing a level of clinical judgment that benefits every participant.

Still have questions? We're happy to walk you through what participation involves — no commitment required.

Talk with Our Team
The Process

Three simple steps to get started

1

Connect With Us

Fill out our short confidential form or give us a call. Tell us a little about yourself and the condition you're dealing with.

2

Screening Visit

Come in to meet our team, discuss your health history, and see if a current study is a good fit. No commitment, no obligation.

3

Begin the Study

If you qualify and choose to participate, we guide you through every step — with our team available to answer questions throughout.

From the Research Desk

Latest Articles

View All Posts

August 21, 2026

Phase 3 Stem Cell Trial for Knee Osteoarthritis Begins in the U.S.

Read Article →

June 4, 2026

Can Meniscus Surgery Make Arthritis Worse? Dr. Mona Hacker on KUSI San Diego

Read Article →

January 2, 2026

Knee Pain & Osteoarthritis Research: Horizon Joins Phase 3 Study in San Diego

Read Article →
Looking for Answers?

New treatments for knee pain, shoulder pain, and joint damage.

If standard care hasn't worked, you're not out of options. Horizon Clinical Research in San Diego conducts FDA-regulated clinical trials evaluating new and investigational treatments for chronic orthopedic conditions — often before they become widely available.

Patients often come to us after searching for things like:

  • "New treatment for knee osteoarthritis"
  • "Alternatives to knee replacement"
  • "Non-surgical knee pain treatment"
  • "Knee pain that won't go away"
  • "Pain going up and down stairs"
  • "Trouble walking due to knee pain"
  • "Shoulder pain at night"
  • "Rotator cuff treatment without surgery"
  • "Cartilage damage treatment options"
  • "Stem cell or regenerative therapy for joints"
  • "Latest clinical trials for arthritis"
  • "Investigational treatments in San Diego"

If any of these sound familiar, a brief screening conversation with our research team can help you understand whether a current clinical study may be appropriate for you.

See If You Qualify
Serving All of San Diego County

Clinical research close to home.

Our research office in La Mesa is centrally located in East County, with easy access from I-8 and SR-125. We welcome participants from across the greater San Diego area.

East County

La Mesa · El Cajon · Lemon Grove · Spring Valley · Santee · Lakeside · Alpine · Ramona · Bonita

Central San Diego

Downtown · Mission Valley · Hillcrest · North Park · South Park · Normal Heights · Kensington · Kearny Mesa

Coastal & Beach Cities

Coronado · Point Loma · Ocean Beach · Mission Beach · Pacific Beach · La Jolla · Del Mar · Solana Beach · Encinitas

North County

Carlsbad · Oceanside · Vista · Escondido · Poway · Rancho Bernardo · Rancho Peñasquitos · Carmel Valley · Mira Mesa · Scripps Ranch

South Bay

Chula Vista · National City · Imperial Beach · Otay Mesa · Eastlake

Work With Us

More than a place for patients.

Horizon is building a network of physician-led research sites across San Diego. Whether you're a physician exploring research or a sponsor seeking capacity, there's a place for you here.

For Physicians

Bring research to your practice.

New to clinical research? We manage the entire site for you — regulatory, staffing, sponsors, and data — so you can focus on caring for patients while adding a new dimension to your practice.

For Physicians →
For Sponsors & CROs

A growing network of sites.

Partner with a proven, physician-led research organization built for fast startup and reliable over-enrollment — now across multiple sites, with a single point of contact.

For Sponsors →

Ready to see if you qualify?

It takes less than two minutes to get started — and there's no commitment involved.

Get in Touch 📞 619.456.6012